Science Journal of Biochemistry
February 2014, Volume 2014, ISSN: 2276-6191
© Author(s) 2014. This work is distributed under the Creative Commons Attribution 3.0 License.
Research Article
Effect Of Alabukun On Hematological Parameters, Liver And Kidney Of Male Albino Rats
Momoh. Johnson* and Manuwa. A.A
*Department of Science Laboratory Technology (Biochemistry Unit),
School of Technology, Lagos State Polytechnic, Ikorodu, Lagos, Nigeria.
Department of Science Laboratory Technology ( Chemistry Unit),
School of Technology, Lagos State Polytechnic, Ikorodu, Lagos, Nigeria.
Accepted 18th January , 2013; Available Online 12 February, 2014
doi: 10.7237/sjbch/191
Abstract:
Alabukun is a local drug containing 760mg acetylsalicylic acid and 60mg caffeine, this drug has been highly abused by Nigerians for the treatment of pains, cold, head ache and feverishness. The present investigation was therefore undertaken to study the effect of Alabukun on the hematological parameters, liver and kidney functions of male albino rats. 24 male albino rats were divided into two groups: Group 1 (control) received no drug while group 2 received Alabukun (31 mg /kg body weight) twice a day for seven days. They were acclimatized for one week before administration of Alabukun commenced. The drug reduceds the RBC count, HGB and HCT values of the treated group compared to the control group. The WBC counts were higher in the treated animals as compared to the untreated animals. There were no significant variation in the body weight, plasma total protein, albumin, plasma cholesterol, TG, HDL- Cholesterol and LDL-Cholesterol. The result indicates that the drug induced marked renal and liver damage characterized by a significant increase (P<0.05) in plasma urea, creatinine, total bilirubin , AST, ALT and ALP values.
Keyword:lactose tolerance, MCM6 gene, African variants, SimpleProbe LightCycler assay