Science Journal of Medicine and Clinical Trials
March 2011,Volume 2011, ISSN: 2276-7487
© Author(s) 2011. This work is distributed under the Creative Commons Attribution 3.0 License.
Research Article
The Influence of Egyptian Propolis on Induced Burn Wound Healing in Diabetic Rats; Antibacterial Mechanism
1Emad T.Ahmed, 2Osama M.Abo-Salem, 1Ali Osman1
1Physical Therapy for Surgery Department, Faculty of Physical Therapy, Cairo University, Egypt.
2Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Egypt.
Accepted March 2011; Available Online March, 2011
doi: 10.7237/sjmct/123
Abstract:
The purpose of the current study was to determine the effectiveness of Egyptian propolis in treating diabetic burn wound. Thirty eight male albino rats were participated in this study for a treatment period of 25 days. They were divided randomly and equally into 4 groups. Rats in the first group had been treated with physiological saline solution (0.9 % Na Cl) daily and served as control group. While patient in 2nd, 3rd, 4th, group received Egyptian propolis, Dermazine (silver sulfadiazine), and Propolis- Dermazine mixture creams daily. Burn surface area and bacterial colony count were used to measure the outcomes at different time interval. Results showed that a significant reduction in both burn surface area and bacterial colony count in creams treated groups compared to control group. Propolis cream was more effective than Dermazine cream, especially on D14 and after that. Interestingly, Propolis- Dermazine mixture significantly decreased bacterial colony count and burn surface area compared to propolis and Dermazine treated group. It could be concluded that propolis alone or in combination with Dermazine is considered a unique antibacterial cream for the treatment of diabetic burn wound.
Keyword:Burn - Diabetes – Wound healing – Propolis - Dermazin