The hypothesis for this research was that intraperitoneal injection of V.amygdalina extract would bring about an increase in sodium excretion and perhaps a reduction in plasma concentration of sodium.Estimation of sodium concentration was carried out on blood samples collected from four group of rats injectedperitoneally with varying concentrations of V amygdalina in normal saline,each group consisting of eight rats.The mean plasma sodium level of groups i, ii, iii and control are 142.38±2.26 mmol/L ,141.0±1.20 ,139.7±1.19 and 137.88±0.83 respctively.These values reveal a proportionate decline in plasma sodium level in response to increasing dosage of extract .V amygdalina aqueous extract perhaps possess natriuretic properties which if harnessed can be used in the treatment of retentive disorders of sodium metabolism.

Keyword: Natriuretic , Sodium ,V .amygdalina

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