Science Journal of Medicine and Clinical Trials
December 2013,Volume 2013, ISSN: 2276-7487
© Author(s) 2013. This work is distributed under the Creative Commons Attribution 3.0 License.
Research Article
Comparison of the Efficacy of Midazolam Vs. Ondansetron in Preventing Post Operative Nausea and Vomiting in Gynecologic Laparoscopic Surgeries:Double-blinded Randomized Clinical Trial Study
Leili Hafizi1, Mahsa Kiafar2, Arash peyvandi3,
Alireza Sepehri Shamloo4, Samira Andalibizadeh5, Masoume Nouri6,
Nahid Zirak7*
1Assistant professor of Obstetrics and Gynecology, Imam Reza Hospital,
Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2Obstetrician and Gynecologist, Imam Reza Hospital, Faculty of Medicine,
Mashhad University of Medical Sciences, Mashhad, Iran.
3Assistant professor of Anesthesiology, Imam Reza Hospital,
Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
4Student Research Committee, School of medicine,
Mashhad University of Medical Sciences, Mashhad, Iran.
5Medical student, Imam Reza Hospital, Faculty of Medicine,
Mashhad University of Medical Sciences, Mashhad, Iran.
6Medical student, Imam Reza Hospital, Faculty of Medicine,
Mashhad University of Medical Sciences, Mashhad, Iran.
7*Associated professor of Anesthesiology, Imam Reza Hospital,
Faculty of Medicine, Cardiac Anesthesia Research Center, Faculty of Medicine,
Mashhad University of Medical Sciences, and Mashhad, Iran.
Accepted 1st November, 2013; Available Online 16 December,2013
doi: 10.7237/sjmct/178
Abstract:
Introduction:Post operative nausea and vomiting (PONV) can be seen more commonly
in women and especially in gynecologic and laparoscopic surgeries. One of
the drugs suggested as a pre-treatment is midazolam. This study
investigated the effect of midazolam in reducing post operative nausea and
vomiting in comparison with ondansetron.
Method:In this double blind randomized clinical trial 80 patients who were met
inclusion and exclusion criteria were randomly allocated in two equal
groups of 40, each receiving either midazolam (received 15 mg/kg during
induction of anesthesia) or ondansetron (4 mg IV, 15 min before
extubation) . Information regarding occurrence of nausea and vomiting in
0, 2, 6 and 24hours after extubation were recorded in a questionnaire.
Results:The nausea score in the recovery, 2, 6 and 24 hours after extubation, was
not significantly different between the two groups.Frequency of vomiting
was higher in midazolam group than ondansetron group at 2 and 6 hours
post recovery, but was the same at 24 hours.
Conclusion:Although midazolam premedication was not more effective than
ondansetron in reducing postoperative nausea and vomiting but in many
intervals the effect was similar to ondansetron; in which justifies its use
with other anti-nausea medications.
Keyword: ondansetron, nausea, vomiting, laparoscopic, gynecologic, midazolam