Objective: To ascertain association of raised BMI with Prolactin levels among infertile males. Methods: A cross sectional study was conducted from june 2010 to May 2011. Sample size was 300 males (147 infertile and 153 healthy fertile control subjects) aged 30 and 60 years, selected from the Jinnah Postgraduate Medical Center (JPMC), Aziz Medical Center and Abbasi Shaheed Hospital, Karachi. All the subjects were grouped to BMI criteria (Ascian pacific region for WHO). They were selected by purposive sampling after a detailed medical history and physical examination. Semen analysis was done and blood samples were collected for serum Prolactin levels. Data was analyzed via SPSS 17.0 by using Analysis of Variances (ANOVA) and independent t test to compare the means and to evaluate the significant association with in the group. Results: No correlation existed between PRL and BMI .Raised BMI appear to have an association with male infertility due to reduction in sperm count in males. Conclusion: Adiposity is confirmed as risk factor for male infertility in local population.

Keyword: BMI, Male Infertility, Prolactin, Azoospermia, Oligospermia.

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